Molecular interaction between natural IgG and ficolin – mechanistic insights on adaptive-innate immune crosstalk
نویسندگان
چکیده
منابع مشابه
Molecular interaction between natural IgG and ficolin – mechanistic insights on adaptive-innate immune crosstalk
Recently, we found that natural IgG (nIgG; a non-specific immunoglobulin of adaptive immunity) is not quiescent, but plays a crucial role in immediate immune defense by collaborating with ficolin (an innate immune protein). However, how the nIgG and ficolin interplay and what factors control the complex formation during infection is unknown. Here, we found that mild acidosis and hypocalcaemia i...
متن کاملInnate-Adaptive Immune Crosstalk
1Department of Biochemistry and Cancer Biology, School of Medicine, Meharry Medical College, Nashville, TN 37208, USA 2Host-Tumor Interactions Research Program, Vanderbilt-Ingram Cancer Center, Vanderbilt University, Nashville, TN 37232, USA 3Cancer Biology Research and Training Program, Department of Biological Sciences, Alabama State University, Montgomery, AL 36104, USA 4Department of Medici...
متن کاملNatural IgG antibodies provide innate protection against ficolin-opsonized bacteria.
For nearly five decades since its discovery, the role of natural IgG, which pre-exists in neonates and uninfected individuals, has remained unclear due to the general perception that natural antibodies lack affinity for pathogens. Here, we show for the first time that natural IgG recognizes a spectrum of bacteria through lectins like ficolin and mannose binding lectin (MBL). Infection-inflammat...
متن کاملInnate-Adaptive Immune Crosstalk 2016
Department of Biochemistry and Cancer Biology, School of Medicine, Meharry Medical College, Nashville, TN 37208, USA Host-Tumor Interactions Research Program, Vanderbilt-Ingram Comprehensive Cancer Center, Vanderbilt University, Nashville, TN 37232, USA Vanderbilt Center for Immunobiology, Vanderbilt University, Nashville, TN 37232, USA Vanderbilt Center for Translational and Clinical Immunolog...
متن کاملCrosstalk between Innate and Adaptive Cells on Allergic Process
Copyright © 2012 Maria Leite-de-Moraes et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. As guest editors of this special issue of the Journal of Allergy, we are pleased to introduce both original article, and reviews that ad...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Scientific Reports
سال: 2014
ISSN: 2045-2322
DOI: 10.1038/srep03675